Capsular contracture post breast reconstruction
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By Editorial Staff. When breast implants, or any other foreign object, are placed in the body, the body forms a lining around it. This lining, or capsule, is formed by your own living tissue. Many people refer to this lining as the "capsule", "tissue capsule", or "scar capsule", although it is not exactly the same thing as scar tissue. This is the body's natural response to a foreign object. Capsule contracture, the most common complication of breast augmentation surgery , can occur at any time.
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What is capsular contracture and how can it be treated?
Removing Hardened Scar Tissue After Breast Surgery
Study record managers: refer to the Data Element Definitions if submitting registration or results information. A 2 arm, 90 patient 45 per cohort trial in patients with breast cancer who will be undergoing mastectomy with immediate tissue-expander reconstruction to determine whether treatment with zafirlukast 20mg PO BID can reduce or prevent the development of capsular contracture. Patients will be block randomized into two cohorts: treatment with zafirlukast and the standard of care, or standard of care alone. Patients will begin treatment with zafirlukast on post-operative day one following placement of tissue expander s once determined safe from a surgical recovery standpoint. They will be continued on the standard dosing 20mg PO twice per day of zafirlukast through expander fill weeks, up to 18 weeks for women receiving radiation. Treatment will be stopped 48 hours prior to expander-implant exchange, which is equivalent to 5 half-lives of the drug. Patients will be seen every weeks for expander fill, and will be assessed clinically based on the Baker classification system of capsular contracture at every appointment.
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Capsular Contracture 101: What You Need to Know
All implants and implanted devices in the body create a normal immune response where a capsule of protective scar tissue collagen fibres forms to envelope the implant. Capsular Contracture is the abnormal contraction or tightening of this capsule around a breast implant. When this happens, the implant may become compressed, deformed, and displaced. Most commonly this is manifested as a tightening of the breast; the breast becomes rounder and seems to sit higher up the chest.
This becomes a problem that warrants a visit to your plastic surgeon. The exact cause of capsular contracture is currently not known. We are not currently unable to accurately predict which patients who undergo breast augmentation may experience capsular contraction related issues. Symptoms typically emerge slowly, starting with an increasing feeling of tightening or firming of the breasts.
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